The Second District Conference was founded in Brooklyn, N.Y. in 1947 shortly after being transferred from the First District which included Massachusetts, Rhode Island, and Connecticut.

When formed the District was composed of five states: New York, New Jersey, Pennsylvania, Delaware, and the Eastern Shore of Maryland.  When the newly formed District was transferred there were eleven chapters and in 1973 there were forty-four chapters (twelve undergraduate, three intermediate, and twenty-nine Graduate Chapters).